Optimization of psoriasis mouse models

Psoriasis, is a common, chronic, autoimmune, inflammatory, relapsing disease, which would benefit from reliable and human-relevant animal models to test drugs pre-clinically understand their mechanism of action. Because its ease use, convenience low cost, the imiquimod (IMQ)-induced psoriasis-like model widely utilized; however, it not known whether all mouse strains are equivalent if hairless appropriate, so that can be further optimized. Under similar experimental conditions, common (BALB/c, C57BL/6J, ApoE) new strain (ApoE/SKH-hr2) as well several inducers (IMQ, IMQ + acetic acid (AcOH) topical AcOH systemic) were compared by clinical, histopathological, biophysical locomotor activity assessments. The BALB/c mice yielded an optimal phenotype with treatment, corresponding phenotypes for other C57BL/6J moderate ApoE mild. In contrast, ApoE/SKH-hr2 mice, result absence Munro abscess in histopathology analysis, left doubt about acquisition. Locomotor treated IMQ, topically systemically showed decreased distance rearing coverage increased immobility treatments. Hence, appears when utilizing application.